If you have a damaged gut biome or are taking over 10'000IU=250ug of Vitamin-D3 then I would consider supplementing with some Vitamin-K2 (10-100%). However I would always recommend adding some magnesium supplementation as this is an essential cofactor to Vitamin-D3 metabolism and th western diet is notoriously deficient.
Healthier patients = a canoe instead of a 25 foot speedboat for your doctor. This is quite a write up. I take 5,000-8,000 IU a day of D3 and that's that. I don't know if there are different "qualities" among manufacturers. I am sure that big pharma has a direct say in establishing MDR's for vitamins and minerals...that's why they are often so low.
I recall reading a book about a guy who took 500,000 IU and suffered no severe problems. I expect so many ills and diseases are from the lack of sufficient vitamins and minerals and it is difficult to know what we are getting in our foods. We know that these substances are natural to the body and required for efficient health and cannot be replaced by big pharma drugs.
I can never trust the medical mafia because they are hell bent for profit and couldn't care less about promoting healthy patients.
Finding a clinical report of adverse results with less than 25'000IU=635ug of Vitamin-D3 daily is hard and this physiological dose can be achieved by good sun bathing. Specialists often say treatment at 30'000IU=750ug is safe and at 40'000IU=1000ug there is cause to have medical supervision in treatment with lab testing, calcium restricted diet. All people should take some magnesium, more if you take more Vitamin-D3.
So comprehensive - thanks! Shocking to me that so few, including MDs are paying attention to this given the early notes during the pandemic that low levels of D3 were a common factor among the most critical. In prior yrs, my doctors always ordered vit D level as part of my bloodwork. It was noted as borderline low. I started supplementing 1,000 IU daily. Subsequent bloodwork showed no improvement. Now supplement 5,000 IU daily. New doctor recently didn't request vit D with my bloodwork. I mistakenly thought it was standard protocol. She wanted to know why I needed it. How can they be so oblivious to what's occurred?!
Yes, deVioleta, it's important to get MK-4. a type of vitamin K2 which the brilliant Dr. Weston Price found back in the 1930s, but it didn’t have a name then, so he called it Activator X. He found it in milk fat (butter) from cows grazing on fast-growing grass. He isolated this nutrient and determined it wasn’t vitamin D. In years of analysis he found that Activator X works with vitamin D to ensure that the higher influx of calcium due to optimum D levels will not be deposited in soft tissue such as joints (arthritis), or the brain (Alzheimer’s), or in the circulatory system (atherosclerosis). He also discovered that MK-4 changes the saliva to be a donor of minerals rather than an extractor, so that dental cavities actually fill in! Besides pastured butter, foods rich in MK-4 are pastured eggs, especially duck and goose eggs, also the fat of these birds. Emu oil is richest. By the way, some researchers say that MK-7, which is made via fermentation, is only absorbed by other bacteria, even in our gut biome we humans don’t benefit from the MK-7 made there. In fact, MK-7 does not cross the placental barrier (MK-4 does). Check at WestonAPrice . org for more info.
Thanks for writing this outstanding article. My patients in general are all skeptical about the potential benefit of any vitamin supplementation. And I practice in a college setting with an educated patient population. I order vitamin d level just to prove they are deficient - otherwise it is unlikely they will take a supplement based on my advise only. I order under the diagnosis of vitamin d deficiency - this is a clinical diagnosis based on northern climate, indoor work and lack of fortified milk/vitamin. - it is rare to get even a low normal level at 25-30. This inspires many patients to supplement. But some lose interest over time and stop the supplement.
I think this may have been less of an issue in the mid-20 century due to regular milk and liver consumption which has fallen by the wayside. This is a public health issue and should be promoted as such at a population level. Unfortunately, many people are simply not interested in long term measures to optimize health and longevity and are skeptical regarding supplements and nutritional advise in general.
Thanks for this. I have been taking 5,000 IU of D3 per the guidelines of the Covid Frontline physicians. Pre covid, I took 2,000 as I was diagnosed with a D deficiency. I wondered if I should maintain the higher dosage. This exhaustive study compilation has answered my question.
When researching I too discovered the notable effect of obesity on the demands for Vitamin-D3 and based on my research came to a similar conclusion to Prof. Wimalawansa and developed a way to quickly determine a starting dose based on weight and height. As everyone is different we can only use these as a starting guide but I believe it is a much better starting point than the sub 800IU=20ug that the public health usually promote.
You can see my handy charts that let you determine your dose in seconds without having to do mental gymnastics.
I thought it was essential to also supplement with K2 when supplementing with vitamin D, but there was no mention of this in the article.
If you have a damaged gut biome or are taking over 10'000IU=250ug of Vitamin-D3 then I would consider supplementing with some Vitamin-K2 (10-100%). However I would always recommend adding some magnesium supplementation as this is an essential cofactor to Vitamin-D3 metabolism and th western diet is notoriously deficient.
Healthier patients = a canoe instead of a 25 foot speedboat for your doctor. This is quite a write up. I take 5,000-8,000 IU a day of D3 and that's that. I don't know if there are different "qualities" among manufacturers. I am sure that big pharma has a direct say in establishing MDR's for vitamins and minerals...that's why they are often so low.
I recall reading a book about a guy who took 500,000 IU and suffered no severe problems. I expect so many ills and diseases are from the lack of sufficient vitamins and minerals and it is difficult to know what we are getting in our foods. We know that these substances are natural to the body and required for efficient health and cannot be replaced by big pharma drugs.
I can never trust the medical mafia because they are hell bent for profit and couldn't care less about promoting healthy patients.
Finding a clinical report of adverse results with less than 25'000IU=635ug of Vitamin-D3 daily is hard and this physiological dose can be achieved by good sun bathing. Specialists often say treatment at 30'000IU=750ug is safe and at 40'000IU=1000ug there is cause to have medical supervision in treatment with lab testing, calcium restricted diet. All people should take some magnesium, more if you take more Vitamin-D3.
So comprehensive - thanks! Shocking to me that so few, including MDs are paying attention to this given the early notes during the pandemic that low levels of D3 were a common factor among the most critical. In prior yrs, my doctors always ordered vit D level as part of my bloodwork. It was noted as borderline low. I started supplementing 1,000 IU daily. Subsequent bloodwork showed no improvement. Now supplement 5,000 IU daily. New doctor recently didn't request vit D with my bloodwork. I mistakenly thought it was standard protocol. She wanted to know why I needed it. How can they be so oblivious to what's occurred?!
Yes, deVioleta, it's important to get MK-4. a type of vitamin K2 which the brilliant Dr. Weston Price found back in the 1930s, but it didn’t have a name then, so he called it Activator X. He found it in milk fat (butter) from cows grazing on fast-growing grass. He isolated this nutrient and determined it wasn’t vitamin D. In years of analysis he found that Activator X works with vitamin D to ensure that the higher influx of calcium due to optimum D levels will not be deposited in soft tissue such as joints (arthritis), or the brain (Alzheimer’s), or in the circulatory system (atherosclerosis). He also discovered that MK-4 changes the saliva to be a donor of minerals rather than an extractor, so that dental cavities actually fill in! Besides pastured butter, foods rich in MK-4 are pastured eggs, especially duck and goose eggs, also the fat of these birds. Emu oil is richest. By the way, some researchers say that MK-7, which is made via fermentation, is only absorbed by other bacteria, even in our gut biome we humans don’t benefit from the MK-7 made there. In fact, MK-7 does not cross the placental barrier (MK-4 does). Check at WestonAPrice . org for more info.
Isn’t there also a relationship between A and D? Are they agonists?
John Campbell has done a large number of vitamin D videos including one just recently.
https://m.youtube.com/watch?v=E3_t-EQIy0s&pp=ygUNSm9obiBjYW1wYmVsbA%3D%3D
Thanks for writing this outstanding article. My patients in general are all skeptical about the potential benefit of any vitamin supplementation. And I practice in a college setting with an educated patient population. I order vitamin d level just to prove they are deficient - otherwise it is unlikely they will take a supplement based on my advise only. I order under the diagnosis of vitamin d deficiency - this is a clinical diagnosis based on northern climate, indoor work and lack of fortified milk/vitamin. - it is rare to get even a low normal level at 25-30. This inspires many patients to supplement. But some lose interest over time and stop the supplement.
I think this may have been less of an issue in the mid-20 century due to regular milk and liver consumption which has fallen by the wayside. This is a public health issue and should be promoted as such at a population level. Unfortunately, many people are simply not interested in long term measures to optimize health and longevity and are skeptical regarding supplements and nutritional advise in general.
Climate change causes pandemics. Vitamin d cannot be allowed to solve this problem. We must eliminate farmers to save lives.
Thanks for this. I have been taking 5,000 IU of D3 per the guidelines of the Covid Frontline physicians. Pre covid, I took 2,000 as I was diagnosed with a D deficiency. I wondered if I should maintain the higher dosage. This exhaustive study compilation has answered my question.
This is a great post.
When researching I too discovered the notable effect of obesity on the demands for Vitamin-D3 and based on my research came to a similar conclusion to Prof. Wimalawansa and developed a way to quickly determine a starting dose based on weight and height. As everyone is different we can only use these as a starting guide but I believe it is a much better starting point than the sub 800IU=20ug that the public health usually promote.
You can see my handy charts that let you determine your dose in seconds without having to do mental gymnastics.
https://cholecalciferol.miraheze.org/wiki/Kalle_Pihlajasaari
Shortly after going on Medicare (Parts A, B, and D) in 2015, my physician ordered a Vitamin D level. My insurance paid for it.